The only opponent who has defeated Edwin De Los Santos is convinced that he can pull off what would be considered a significant upset in the biggest fight of De Los Santos’ career.

William Foster III sees Shakur Stevenson-De Los Santos as an evenly matched fight that could go either way November 16 at T-Mobile Arena in Las Vegas. BetMGM sportsbook has established Stevenson as a 14-1 favorite in advance of a 12-round, 135-pound title fight ESPN will televise.

“I think that he has a legit chance to win,” Foster told BoxingScene.com. “This is a good opportunity for Stevenson, too, because he’s trying to fight ‘Tank’ [Gervonta Davis]. I never fought ‘Tank’ before, but I would assume he punches pretty hard and if [Stevenson] can withstand De Los Santos’ punches it’ll make him that much more comfortable fighting ‘Tank.’ So, this is a huge opportunity for both of them. I can’t wait to see what happens.”

Foster (16-0, 10 KOs, 1 NC) edged De Los Santos (16-1, 14 KOs) by split decision in an eight-rounder Showtime televised as part of its “ShoBox: The New Generation” series in February 2022 from Caribe Royale Orlando in Orlando, Florida. The New Haven, Connecticut native has his own important fight scheduled for Saturday night, when he’ll oppose Puerto Rican southpaw Henry Lebron (18-0, 10 KOs) in a 10-round bout on the Efe Ajagba-Joe Goodall undercard at Tahoe Blue Event Center in Stateline, Nevada.

“[Beating Lebron] would get me one step closer to being a world champion,” Foster said. “He fought OK competition. I think his style and flair brought a lot of attention to him, especially to his Puerto Rican community. He has a great fan base. I think he’s a real good fighter. … I’m surprised he took the fight, but I’m glad he did.”

ESPN+ will stream the Lebron-Foster fight as part of a show scheduled to start Saturday at 6 p.m. EDT and 3 p.m. PDT.

As much as Foster wants a shot at a 130-pound world title, the 30-year-old contender will be rooting for De Los Santos (16-1, 14 KOs) to beat Stevenson (20-0, 10 KOs) because his potential rematch with De Los Santos would then become more marketable.

“I would want him to win,” Foster said. “He defeats Stevenson and he’s top dog at 135. I would like to fight him again after I get my world title.”

Stevenson, a two-division champion from Newark, New Jersey, is considered the superior boxer, but Brooklyn’s De Los Santos has knocked out 82 percent of his pro opponents.

“It only takes one shot to catch someone off guard and to finish the fight,” Foster said. “But I think it’ll be a very good fight. … It should be very entertaining, too, just to see where both of them are at mentally.”

Stevenson, 26, and De Los Santos, 24, will fight for the vacant WBC lightweight title. The WBC designated undisputed lightweight champ Devin Haney (30-0, 15 KOs) as its 135-pound champion in recess because Haney has moved up to the 140-pound division to challenge WBC super lightweight champ Regis Prograis (29-1, 24 KOs) on December 9 at Chase Center in San Francisco.

Keith Idec is a senior writer/columnist for BoxingScene.com. He can be reached on Twitter @Idecboxing.