Eight division champion Manny Pacquiao has no issue with facing Errol Spence next - if the WBC, IBF welterweight champion receives a clean bill of health.

Pacquiao was scheduled to face Spence in the main event of a Fox Sports pay-per-view card on August 21 at the T-Mobile Arena in Las Vegas.

However, on Tuesday it was revealed that Spence was forced to withdraw after an eye injury was discovered during a pre-fight medical examination by the Nevada State Athletic Commission.

Pacquiao will now face WBA welterweight champion Yordenis Ugas, who was already scheduled to see action on the undercard. Ironically, Ugas' scheduled opponent, Fabian Maidana, also withdrew after suffering a bad cut during a sparring session.

The 42-year-old Pacquiao has been out of the ring since July of 2019, when he picked up a twelve round decision over Keith Thurman to capture the WBA title.

Pacquiao would eventually get made the "champion in recess" due to inactivity. And as a result, the WBA made Ugas the "super" champion in the weight class.

Now the Filipino star has the opportunity to reclaim the belt.

"I still consider it a good fight, a hard fight. I will not be taking this fight lightly. I have to make sure that I’m not overconfident," Pacquiao told TMZ Sports.

Should everything go well with Ugas, Pacquiao has no problem with another scheduled fight with Spence - this time around with three world titles at stake.

"I have no problem [fighting Spence]. As long as he’s still physically fit, then okay," Pacquiao says.

Back in late 2019, Spence suffered injuries in a serious car accident. He returned to the ring in December 2020 and picked up a dominant twelve round decision win over Danny Garcia.